Table 3. Results of the Cox regression analyses for relapse-free survival.
| Univariate | p-value | Multivariate1 | p-value | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Preoperatively measured biomarkers | ||||
| YKL-40 | 1.19 (1.07–1.32) | <0.001 | 1.08 (0.96–1.22) | 0.212 |
| IL-6 | 1.15 (1.03–1.28) | 0.010 | 1.04 (0.91–1.18) | 0.566 |
| CRP | 1.08 (0.96–1.21) | 0.219 | 1.03 (0.88–1.20) | 0.756 |
| CEA | 1.01 (0.96–1.07) | 0.583 | 1.00 (0.93–1.07) | 0.952 |
| CA19-9 | 1.08 (1.03–1.14) | <0.001 | 1.12 (1.06–1.19) | <0.001 |
| 0 elevated (N = 111) | Reference | Reference | ||
| 1 elevated (N = 113) | 0.81 (0.58–1.12) | 0.202 | 0.81 (0.58–1.12) | 0.202 |
| 2 elevated (N = 101) | 1.13 (0.83–1.56) | 0.438 | 1.21 (0.87–1.68) | 0.252 |
| 3 elevated (N = 44) | 1.60 (1.08–2.36) | 0.018 | 1.63 (1.08–2.47) | 0.021 |
| 4 elevated (N = 29) | 1.57 (0.99–2.49) | 0.055 | 1.88 (1.12–3.16) | 0.016 |
| 5 elevated (N = 1) | 2.86 (0.40–20.7) | 0.298 | 3.60 (0.48–26.8) | 0.211 |
| 0–1 elevated (N = 224) | Reference | Reference | ||
| 2–5 elevated (N = 175) | 1.37 (1.10–1.72) | 0.005 | 1.40 (1.11–1.78) | 0.005 |
| Postoperatively measured biomarkers | ||||
| YKL-40 | 1.21 (1.09–1.34) | <0.001 | 1.06 (0.94–1.19) | 0.323 |
| IL-6 | 1.11 (1.01–1.23) | 0.033 | 0.98 (0.87–1.11) | 0.755 |
| CRP | 1.07 (0.99–1.15) | 0.075 | 1.02 (0.92–1.12) | 0.741 |
| CEA | 1.24 (1.14–1.34) | <0.001 | 1.17 (1.07–1.29) | <0.001 |
| CA19-9 | 1.12 (1.04–1.20) | 0.002 | 1.09 (1.01–1.17) | 0.029 |
| 0 elevated (N = 137) | Reference | Reference | ||
| 1 elevated (N = 99) | 1.18 (0.87–1.62) | 0.290 | 1.00 (0.73–1.38) | 0.993 |
| 2 elevated (N = 106) | 1.41 (1.05–1.91) | 0.023 | 1.30 (0.95–1.78) | 0.102 |
| 3 elevated (N = 48) | 1.98 (1.37–2.86) | <0.001 | 1.84 (1.25–2.71) | 0.002 |
| 4 elevated (N = 10) | 2.94 (1.48–5.86) | 0.002 | 2.50 (1.22–5.12) | 0.012 |
| 5 elevated (N = 3) | 3.67 (1.16–11.7) | 0.028 | 3.14 (0.97–10.1) | 0.055 |
| 0–1 elevated (N = 236) | Reference | Reference | ||
| 2–5 elevated (N = 167) | 1.54 (1.23–1.92) | <0.001 | 1.57 (1.24–1.98) | <0.001 |
1 Variables included in the multivariate analyses: serum values of IL-6, YKL-40, CRP, CEA, and CA19-9; age; gender; location of the primary tumor; type of liver metastases (synchronous/metachronous; Table 1); type of liver resection (minor/major; Table 1); the number and size of the liver metastases; and the resection margins (R0/1/2). The biomarkers are presented as log2-transformed continuous variables.