Table 4. Results of the Cox regression analyses in relation to overall survival.
| Univariate | p-value | Multivariate1 | p-value | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Preoperatively measured biomarkers | ||||
| YKL-40 | 1.29 (1.16–1.44) | <0.001 | 1.19 (1.04–1.35) | 0.010 |
| IL-6 | 1.16 (1.03–1.30) | 0.011 | 1.03 (0.90–1.18) | 0.685 |
| CRP | 1.07 (0.95–1.21) | 0.240 | 0.91 (0.77–1.06) | 0.215 |
| CEA | 1.07 (1.01–1.12) | 0.019 | 1.02 (0.95–1.09) | 0.602 |
| CA19-9 | 1.12 (1.06–1.18) | <0.001 | 1.13 (1.06–1.20) | <0.001 |
| 0 elevated (N = 111) | Reference | Reference | ||
| 1 elevated (N = 113) | 0.86 (0.60–1.24) | 0.433 | 0.82 (0.57–1.18) | 0.284 |
| 2 elevated (N = 101) | 1.63 (1.16–2.30) | 0.005 | 1.58 (1.11–2.24) | 0.011 |
| 3 elevated (N = 44) | 1.82 (1.19–2.79) | 0.006 | 1.60 (1.02–2.50) | 0.042 |
| 4 elevated (N = 29) | 1.78 (1.08–2.93) | 0.023 | 1.75 (1.01–3.04) | 0.046 |
| 5 elevated (N = 1) | 3.24 (0.45–23.5) | 0.245 | 2.90 (0.39–21.7) | 0.299 |
| 0–1 elevated (N = 224) | Reference | Reference | ||
| 2–5 elevated (N = 175) | 1.76 (1.39–2.24) | <0.001 | 1.71 (1.33–2.21) | <0.001 |
| Postoperatively measured biomarkers | ||||
| YKL-40 | 1.26 (1.13–1.41) | <0.001 | 1.10 (0.97–1.24) | 0.131 |
| IL-6 | 1.13 (1.02–1.26) | 0.022 | 0.95 (0.83–1.09) | 0.498 |
| CRP | 1.11 (1.02–1.20) | 0.011 | 1.09 (0.99–1.20) | 0.096 |
| CEA | 1.33 (1.22–1.46) | <0.001 | 1.24 (1.12–1.36) | <0.001 |
| CA19-9 | 1.22 (1.13–1.31) | <0.001 | 1.17 (1.08–1.28) | <0.001 |
| 0 elevated (N = 137) | Reference | Reference | ||
| 1 elevated (N = 99) | 1.03 (0.72–1.47) | 0.882 | 0.88 (0.61–1.27) | 0.488 |
| 2 elevated (N = 106) | 1.57 (1.13–2.17) | 0.007 | 1.40 (0.99–1.97) | 0.055 |
| 3 elevated (N = 48) | 2.42 (1.64–3.56) | <0.001 | 2.33 (1.56–3.48) | <0.001 |
| 4 elevated (N = 10) | 4.45 (2.21–8.96) | <0.001 | 4.42 (2.16–9.05) | <0.001 |
| 5 elevated (N = 3) | 10.2 (3.16–32.9) | <0.001 | 8.91 (2.71–29.2) | <0.001 |
| 0–1 elevated (N = 236) | Reference | Reference | ||
| 2–5 elevated (N = 167) | 1.83 (1.44–2.33) | <0.001 | 1.84 (1.43–2.37) | <0.001 |
1 Variables included in the multivariate analyses: serum values of IL-6, YKL-40, CRP, CEA, and CA19-9; age; gender; location of the primary tumor; type of liver metastases (synchronous/metachronous; Table 1); type of liver resection (minor/major; Table 1); the number and size of the liver metastases; and the resection margins (R0/1/2). The biomarkers are presented as log2-transformed continuous variables.