Table 3.
Multivariate analyses of clinical factors for PFS and OS
| PFS | OS | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
|
ECOG
PS 0–1 vs 2 |
BM
Present |
1.31 (0.62 to 2.73) |
0.48 | 1.06 (0.43 to 2.61) |
0.93 |
|
BM
Absent |
0.54 (0.33 to 0.89) |
0.02 | 0.29 (0.16 to 0.50) |
<0.001 | |
|
PD-L1 expression
90%–100% vs 50%–89% |
0.67 (0.48 to 0.93) |
0.02 | 0.59 (0.39 to 0.89) |
0.01 | |
|
Smoking status
Ever vs never |
0.74 (0.43 to 1.28) |
0.28 | 1.04 (0.52 to 2.10) |
0.90 | |
BM, brain metastases; ECOG PS, Eastern Cooperative Oncology Group Performance Status; PD-L1, programmed cell death ligand 1.