Table 4. Statistics table of smoking history by mutation in the 833 samples.

Smoking history	Mutation
	ALK	BRAF	EGFR	KRAS	PIK3CA	HER2	OTHERS	Total
Never
Frequency	0	1	24	7	0	0	25	57
Expected	0.07	0.62	3.97	14.16	0.68	0	37.5
Chi-square	0.07	0.24	101.06	3.62	0.68	0	4.17
Ever
Frequency	1	8	34	200	10	0	523	776
Expected	0.93	8.38	54.03	192.84	9.32	0	510.5
Chi-square	0.0053	0.017	7.43	0.27	0.05	0	0.31
Total	1	9	58	207	10	0	548	833

There is strong evidence of an association.