Table 6. Validity parameters for selected markers when used as a test to predict periodontitis among subjects with no diabetes (smaller values of the marker are predictive of a positive diagnosis).

Positive if < cut-off value	Sensitivity	Specificity	Accuracy	PPV at pretest probability =		NPV at pretest probability = 10%
				50%	90%
Standardized Ct value-mir155
5.890 (Highest specificity)	53.3	100.0	76.7	100.0	100.0	95.1
8.975 (Optimum cut-off value)	86.7	78.6	82.6	80.2	97.3	98.1
10.740 (Highest sensitivity)	100.0	35.7	67.9	60.9	93.3	100.0
Standardized Ct value-mir146b
7.810 (Highest specificity)	46.7	100.0	73.3	100.0	100.0	94.4
11.040 (Optimum cut-off value)	93.3	64.3	78.8	72.3	95.9	98.9
12.400 (Highest sensitivity)	100.0	42.9	71.4	63.6	94.0	100.0
Standardized Ct value-mir203
6.090 (Highest specificity)	46.7	100.0	73.3	100.0	100.0	94.4
7.705 (Optimum cut-off value)	73.3	78.6	76.0	77.4	96.9	96.4
11.175 (Highest sensitivity)	100.0	14.3	57.1	53.8	91.3	100.0
Standardized Ct value-mir146a
8.970 (Highest specificity)	20.0	100.0	60.0	100.0	100.0	91.8
11.705 (Optimum cut-off value)	60.0	85.7	72.9	80.8	97.4	95.1
15.350 (Highest sensitivity)	100.0	28.6	64.3	58.3	92.6	100.0