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. 2020 Aug 4;8(2):e000656. doi: 10.1136/jitc-2020-000656

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Left hand side: DIXON MRI (in and opposed phase) were used to compute a bone mask of the spine (highlighted in the positron emission tomography (PET) maximum intensity projection image), which was copied to the PET images to assess the standardized uptake value lean body mass (SULmean) of the bone marrow. Right hand side: example of a responder (patient no. 10, also shown in online supplementary figure S2) and a non-responder (patient no. 11) to checkpoint inhibitor therapy. Note the changes of [¹⁸F]-labeled fluorodeoxyglucose (¹⁸F-FDG)-uptake in the bone marrow in the responder especially at t₁ while there was no significant change observed in the non-responder.