Table 1.

Event rates in standard strategy and treatment effect estimates of cinacalcet strategy

	Annual event rates in standard strategy, first (subsequent) event		Effect size as measured by HR (95% CI), cinacalcet strategy versus standard strategy			Source
Health state	ITT	Lag-censoring	ITT unadjusted	ITT covariate-adjusted*	Lag-censoring*
All-cause death	0.10 (NA)	0.10 (NA)	0.94 (0.85 to 1.04)	0.87 (0.78 to 0.97)	0.80 (0.69 to 0.91)	17
Cardiovascular event†	0.08 (0.43)	0.10 (0.57)	0.86 (0.76 to 0.98)	0.85 (0.74 to 0.97)	0.78 (0.67 to 0.91)	17
Bone fracture	0.04 (0.11)	0.04 (0.11)	0.89 (0.75 to 1.07)	0.86 (0.72 to 1.04)	0.73 (0.59 to 0.92)	17
Parathyroidectomy	0.05 (NA)	0.05 (NA)	0.44 (0.36 to 0.54)	0.42 (0.34 to 0.51)	0.25 (0.19 to 0.33)	17

*Adjusted for baseline covariates: age, sex, race, region, body mass index, time on dialysis, history of CV disease, blood pressure, diabetes, retinopathy, tobacco use, type of vascular access, HDL, calcium–phosphate product and albumin.

†Myocardial infarction, hospitalisation for unstable angina, heart failure or peripheral vascular event.

CI, confidence interval; CV, cardiovascular; HDL, high-density lipoprotein; ITT, intent to treat.