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. 2020 Aug 5;7(1):16–25. doi: 10.1016/j.jacep.2020.07.016

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© 2021 by the American College of Cardiology Foundation. Published by Elsevier.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Central Illustration — Prolongation of the QTc Interval in Hospitalized Patients With COVID-19

Examples of lead II ECG recordings from a patient admitted with severe COVID-19 infection at baseline (top left) and after 5 days of treatment with HCQ/AZM (bottom left) demonstrating significant prolongation of the QTc interval. Changes in the QTc interval after administration of HCQ/AZM compared to baseline values are shown (right panel). Patients that did not survive hospitalization are designated by solid red markers. COVID-19 = coronavirus disease-2019; ECG = electrocardiography; HCQ/AZM = hydroxychloroquine and azithromycin; QTc = corrected QT interval.