Table 1.
Patient Characteristics of the Screened Population, and Comparison of Patients Included Versus Patients Excluded From the Analysis
| All Patients (N = 586) | Included (n = 415) | Excluded (n = 171) | p Value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age (yrs) | 64 ± 15 | 65 ± 15 | 62 ± 15 | 0.022 |
| Female | 261 (45) | 178 (43) | 83 (49) | 0.235 |
| Caucasian | 205 (35) | 147 (35) | 58 (34) | 0.775 |
| African American | 305 (52) | 211 (51) | 94 (55) | 0.413 |
| BMI (kg/m2) | 32 ± 9 | 32 ± 9 | 32 ± 8 | 0.631 |
| Comorbidities | ||||
| Hypertension | 303 (52) | 219 (53) | 84 (49) | 0.467 |
| Coronary artery disease | 64 (11) | 49 (12) | 15 (9) | 0.311 |
| Heart failure | 37 (6) | 30 (7) | 7 (4) | 0.192 |
| Atrial fibrillation | 40 (7) | 31 (8) | 9 (5) | 0.374 |
| Chronic kidney disease | 39 (7) | 27 (7) | 12 (7) | 0.856 |
| Diabetes mellitus | 176 (30) | 132 (32) | 44 (26) | 0.165 |
| Chronic lung disease | 43 (7) | 33 (8) | 10 (6) | 0.486 |
| Cigarette smoker | 14 (2) | 9 (2) | 5 (3) | 0.563 |
| Cancer | 80 (14) | 58 (14) | 22 (13) | 0.792 |
| Laboratory values | ||||
| Creatinine (mg/dl)∗ | 1.8 ± 2.1 | 1.8 ± 2.2 | 1.6 ± 1.8 | 0.294 |
| Aspartate aminotransferase (U/l)∗ | 66 ± 165 | 69 ± 194 | 60 ± 45 | 0.417 |
| Alanine aminotransferase (U/l)∗ | 48 ± 163 | 51 ± 193 | 44 ± 38 | 0.544 |
| Lactic acid (mmol/l)∗ | 1.8 ± 1.9 | 1.8 ± 1.9 | 1.7 ± 2.0 | 0.565 |
| Potassium (mmol/l)† | — | 4.2 ± 0.6 | N/A | — |
| Magnesium (mg/dl) | — | 2.0 ± 0.4 | N/A | — |
| Maximum troponin I (ng/ml) | — | 0.4 ± 2.3 | N/A | — |
| Baseline electrocardiographic parameters | ||||
| QRS duration (ms) | 90 ± 18 | 91 ± 20 | 87 ± 14 | 0.018 |
| QTc (ms) | 440 ± 26 | 443 ± 25 | 436 ± 27 | 0.009 |
| Heart rate | 91 ± 17 | 91 ± 18 | 90 ± 16 | 0.729 |
| Baseline rhythm | ||||
| Normal sinus | 505 (86) | 379 (91) | 126 (95) | 0.136 |
| Atrial fibrillation | 34 (6) | 28 (7) | 6 (5) | 0.416 |
| Paced | 5 (1) | 5 (1) | 0 (0) | — |
| Junctional | 3 (0) | 3 (1) | 0 (0) | — |
Values are mean ± SD or n (%).
SI units for creatinine (μmol/l) = mg/dl × 88.4.
SI units for magnesium (μmol/l) = mg/dl × 0.4114.
SI units for troponin I (μg/l) = ng/ml × 1.
BMI = body mass index.
∗
Admission laboratory values.
†
Laboratory values at the time of initiation of hydroxychloroquine and azithromycin (HCQ/AZM)