Table 3.
Results From Proportional Hazards Cox Analysis of Association Between Time-Dependent Changes in QTc Following Concomitant HCQ/AZM Administration, and Con-Current Mortality
| HR | 95% CI | p Value (2-sided) | |
|---|---|---|---|
| Patients with complete QTc data from baseline, and days 1, 2 or 3, 4 or 5 (n = 137) | |||
| Changes in QTc (time varying) | 1.004 | 0.996−1.012 | 0.367 |
| Baseline QTc (from ECG) | 1.014 | 0.998−1.031 | 0.094 |
| Days from admission to combo administration | 1.068 | 0.947−1.204 | 0.283 |
| Age at admission | 1.087 | 1.045−1.131 | <0.0001 |
| Male | 1.295 | 0.613−2.736 | 0.499 |
| BMI | 1.065 | 1.003−1.130 | 0.039 |
| Race (White or Caucasian) | 0.617 | 0.270−1.410 | 0.252 |
| All patients (N = 415) | |||
| Changes in QTc (time varying) | 0.998 | 0.992−1.005 | 0.607 |
| Baseline QTc (from ECG) | 1.004 | 0.994−1.014 | 0.457 |
| Days from admission to combo administration | 1.081 | 0.996−1.173 | 0.064 |
| Age at admission | 1.064 | 1.042−1.086 | <0.0001 |
| Male | 0.818 | 0.526−1.271 | 0.371 |
| BMI | 1.017 | 0.993−1.040 | 0.164 |
| Race (White or Caucasian) | 0.962 | 0.606−1.525 | 0.868 |