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. 2020 Jul 9;5(13):e135121. doi: 10.1172/jci.insight.135121

Figure 7. Pathological ocular lymphangiogenesis.

Figure 7

(A–C) Short lymphatic sprouts are found in the nasal-side limbal lymphatics. Lateral views of the nasal side (A) and temporal side (B) of a healthy Prox1-tdTomato mouse eye (8 weeks) demonstrate the predominant presence of limbal lymphatic sprouts in the nasal side. A part of the nasal and temporal lymphatics was enlarged and shown in the insets. Black arrows, sprouts from the limbal lymphatic vessel; black arrowhead, the limbal lymphatic vessel; S, Schlemm’s canal; me, medial rectus muscle. (C) The number of limbal lymphatic sprouts in the nasal versus temporal quadrant was quantified (n = 6, both sexes). (D–F) Extensive corneal lymphangiogenesis in the postnatal Prox1-EGFP rat eye (P7) due to unknown causes. White arrows point to Schlemm’s canal, and a bracket marks active corneal lymphangiogenesis. Boxed areas in panel D are enlarged in panels E and F, respectively. (G–I) Concurrent occurrence of developmental (arrowhead-marked) and pathological (arrow-marked) lymphangiogenesis detected in the eye of a Prox1-EGFP neonate mouse (P0.5). Boxed areas in panel G are enlarged in panels H (original magnification, ×2) and I (original magnification, ×2.2), respectively.