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. 2020 Jun 18;5(12):e138070. doi: 10.1172/jci.insight.138070

Figure 3. Postmortem lung biopsy specimens from case 1.

Figure 3

(A) Lung tissue showing pulmonary edema with hyaline membranes and desquamation of alveolar epithelial cells (H&E staining; original magnification, ×200). (B) Ultrastructural image showing cytoplasmic viral particles in a type II pneumocyte (arrow), with swollen mitochondria and dilated endoplasmic reticulum (original magnification, ×20,000). (C) CK7+ cells reflecting pneumocytes (original magnification, ×200). (D) SPB+ cells indicating type II pneumocytes with marked vacuolation and mild hyperplasia (original magnification, ×200). (E) Increased CD68+ macrophages with cytomegaly mainly in alveolar spaces (original magnification, ×200). (F) Immunohistochemical staining for MPO, indicating a large number of interstitial infiltrated polymorphonuclear cells (original magnification, ×200). (G) CD4+ and (H) CD8+ T cells distributed in the alveolar septal walls and interstitial areas (original magnification, ×200). (I) Gasdermin D positivity indicating cell pyroptosis (original magnification, ×200). (J and K) TUNEL staining showing apoptotic cells (original magnification, ×200). (L) RNAscope in situ hybridization indicating SARS-CoV-2 nucleic acids, which manifest as spotted brown particles (original magnification, ×200).