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. 2020 Jun 18;5(12):e135348. doi: 10.1172/jci.insight.135348

Figure 3. Sustained ARC-AAT treatment restored hepatocyte ultrastructure.

Figure 3

EM images compare hepatocytes from a naive C57BL/6 WT mouse, 11 months old (A and B); PiZ mouse at baseline, 3 months old (C and D); PiZ mouse IV injected with saline (Q2W) for 33 weeks, 11 months old (E and F); and PiZ mouse IV injected (Q2W) with 8 mg/kg ARC-AAT for 33 weeks, 11 months old (G and H). G, globule; N, nucleus; m, healthy mitochondrion; ER, endoplasmic reticulum; black arrowheads, damaged mitochondria; white arrowheads, autophagosomes. Scale bars: 500 nm (A, C, D, and H), 1 μm (B, E, and G), 800 nm (F).