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. 2020 Jul 9;5(13):e134749. doi: 10.1172/jci.insight.134749

Figure 4. Platelet CLEC-2 deficiency reduces release of complement inhibitors from platelets in early sepsis.

Figure 4

(A–E and G) Plasma levels of different complement inhibitors, PF4, P selectin, and ATP in WT and Plt Clec-2–/– mice with or without E. coli injection. (F) P selectin–positive platelets in WT and Plt Clec-2–/– mice with or without E. coli injection. The data represent mean ± SD, n = 9 mice/group. #P < 0.05, comparing the sample at 0 hours of E. coli injection with samples at other time points after E. coli infection. *P < 0.05. **P < 0.01. ***P < 0.001. Data were analyzed using 1-way ANOVA followed by Tukey’s test for multiple groups and were representative of 3 independent experiments.