Figure 8. Injection of complement inhibitors released from platelets protects liver function in early sepsis.

Plasma levels of (A) complement inhibitors, (B–D) liver function biomarkers, and (E and F) mRNA transcripts of the liver of WT or mutant mice injected with E. coli or saline for 8 hours. Some infected mutant mice were injected with the supernatant of podoplanin-pretreated WT or Clec-2^–/– platelets at 1 hour after E. coli infection. Data represent mean ± SD. *P < 0.05. **P < 0.01. n = 6 mice/group. Data were analyzed using 2-way ANOVA followed by Tukey’s test for multiple groups and were representative of 3 independent experiments.