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. 2020 Jun 18;5(12):e137262. doi: 10.1172/jci.insight.137262

Figure 4. Longitudinal analysis of PfEMP1 variant–specific IgG over multiple malaria seasons.

Figure 4

IgG reactivity specific to PfEMP1 variants was determined for 60 children ages 6 months to 8 years at 5 cross-sectional surveys before the malaria season. (A) Malaria incidence over 5 malaria seasons for 60 children aged 6 months to 2 years; 3–5 years; and 6–8 years (n = 20 per age group). Plus signs along the left margin indicate subjects with asymptomatic P. falciparum parasitemia at enrollment. The bubble area is proportional to parasite density determined at each visit. (B) The number of malaria episodes per 2-week period by age group over 5 malaria seasons. (C) Longitudinal IgG reactivity at 5 cross-sectional surveys in the same children.