Figure 8.

Schematic representation of the model of activation of TFEB in WT and CnB^scko after injury. Calcineurin acts a phosphatase for TFEB, whereas mTORC1 is a known inhibitor of TFEB. After injury, when calcineurin is present, the activation of TFEB by calcineurin dephosphorylation overwhelms the inhibitory effect of mTORC1, causing an increase in nuclear TFEB. However, when calcineurin is deleted, such as in CnB^scko animals, high mTORC1 activity causes TFEB phosphorylation and inhibition of activity. We hypothesize that decreased TFEB activation in CnB^scko nerves impairs autophagy activation and delays myelin clearance after injury.