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. 2020 Jul 9;5(13):e138295. doi: 10.1172/jci.insight.138295

Figure 7. Proposed model of scleraxis role in adult tendon growth response to mechanical loading.

Figure 7

In WT (left) scleraxis controls the differentiation of CD146+ pericytes into a tenogenic lineage. When scleraxis is deleted (right), CD146+ cells still migrate to the neotendon but are unable to differentiate and do not participate in ECM synthesis.