Figure 5. IgG3 binding antibody responses as measured by binding antibody multiplex assay against consensus Env gp140 and Env gp41.

Positive responses are shown in filled circles in color; negative responses are shown in open gray triangles. Box plots represent the distribution for the positive responders only (the upper and lower quartiles and the median). Bar plots show response rates. Numbers below the bars indicate numbers of positive responders and total participants. Positive response rates were compared using the Fisher exact test for unpaired data (between treatment groups) and the McNemar test for paired data (between visits). Response magnitudes among positive responders were compared using the Wilcoxon rank sum test for unpaired data and the Wilcoxon signed rank test for paired data. All P values are 2 sided. False discovery rate–adjusted q values were calculated to account for multiple antigens, multiple time points, or treatment groups.