Figure 6. Antibody functional responses.

(A) Neutralizing antibody responses to tier 1A Env-pseudotyped virus MW965.26 as determined by the TZM-bl neutralization assay 2 weeks after the third and fourth vaccinations. (B) ADCP 2 weeks after the fourth vaccination. (C) ADCC as determined by the infected cell target assay for a clade C viral isolate (TV1). For all plots, positive responses are shown in filled circles in color; negative responses are shown in open gray triangles. Box plots represent the distribution for the positive responders only (the upper and lower quartiles and the median). Response rates are listed above each graph along with numbers of positive responders and total participants. Response magnitudes among positive responders were compared using the Wilcoxon signed rank test; P values are 2 sided.