Table 2.

Changes in serum liver test during the administration of sequences A and B in three different times. Comparation in serum liver tests during the administration of sequences A and B in three different times (T0, T1 and T2). There were no significant changes in the test results, indicating that there are no differences between the drugs. These results showed the therapeutic efficacy of the drug manufactured in capsules and tablets relative to the standard drug.

Laboratory parameters	Sequence A Tablets= > Capsules (n = 15)			Sequence B Capsules= > Tablets (n = 15)			P value
	T0	T1	T2	T0	T1	T2
Alkaline phosphatase (U/L)	155.20 ± 120.03	149.30 ± 90.83	156.40 ± 110.15	97.00 ± 31.31	105.27 ± 49.06	101.20 ± 31.79	0.888
Gamma glutamyl transferase (U/L)	95.13 ± 126.14	95.47 ± 121.81	96.07 ± 120.11	116.33 ± 113.13	136.67 ± 162.93	117.33 ± 118.11	0.579
Alanine aminotransferase (U/L)	32.00 ± 31.33	33.93 ± 39.06	35.13 ± 40.23	39.57 ± 21.15	35.07 ± 17.94	53.53 ± 75.89	0.579
Aspartate aminotransferase (U/L)	31.33 ± 21.07	31.93 ± 22.75	32.87 ± 21.55	36.51 ± 14.85	34.53 ± 10.45	46.53 ± 44.89	0.917
Total bilirubin (mg/dL)	0.60 ± 0.33	0.63 ± 0.31	0.62 ± 0.35	0.60 ± 0.31	0.58 ± 0.22	0.56 ± 0.21	0.590