Table 5.
The risks of nulliparity and grand multiparity for dementia according to subtypes and geographical regions
| Numbers of subjects | All-cause dementia | AD | VaD | NAVD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Dementia | AD | VaD | NAVD | OR (95 CI)* | P | OR (95 CI)* | P | OR (95 CI)* | P | OR (95 CI)* | P | |
| Nulliparity | |||||||||||||
| Asia | 239/5584 | 27/336 | 17/244 | 1/27 | 7/54 | 2.15 (1.33–3.47) | 0.002 | 1.91 (1.07–3.39) | 0.028 | 1.03 (0.13–7.89) | 0.977 | 3.47 (1.44–8.35) | 0.005 |
| Europe | 117/3098 | 25/125 | 12/88 | 1/22 | 1/12 | 0.70 (0.38–1.30) | 0.261 | 0.90 (0.46–1.76) | 0.761 | 0.28 (0.04–2.13) | 0.218 | 0.53 (0.06–4.32) | 0.552 |
| Latin America | 2456/270 | 32/245 | 15/129 | 4/24 | 13/89 | 0.91 (0.59–1.40) | 0.661 | 0.72 (0.40–1.30) | 0.277 | 1.39 (0.42–4.57) | 0.585 | 1.11 (0.58–2.14) | 0.746 |
| Grand multiparity | |||||||||||||
| Asia | 919/5584 | 132/336 | 102/244 | 10/27 | 1/54 | 1.25 (0.94–1.67) | 0.122 | 1.29 (0.93–1.79) | 0.127 | 1.37 (0.55–3.42) | 0.498 | 1.22 (0.61–2.43) | 0.581 |
| Europe | 117/3098 | 39/125 | 6/88 | 3/22 | 1/12 | 2.99 (1.38–6.47) | 0.005 | 2.42 (0.94–6.25) | 0.068 | 6.86 (1.81–26.08) | 0.005 | 3.36 (0.37–30.80) | 0.283 |
| Latin America | 702/2456 | 70/245 | 30/129 | 9/24 | 28/89 | 1.49 (1.04–2.12) | 0.028 | 1.25 (0.77–2.03) | 0.366 | 1.41 (0.53–3.79) | 0.495 | 1.80 (1.05–3.10) | 0.034 |
AD Alzheimer’s disease, VaD vascular dementia, NAVD non-Alzheimer non-vascular dementia, OR odds ratio, CI confidence intervals
*Binary or multinomial logistic regression analyses that employed the women with 1 to 4 parities as the referent group and adjusted age, educational level, hypertension, diabetes mellitus, and cohort as covariates using the pooled dataset of 9 cohort studies that provided the type of dementia (Cuban Health and Alzheimer Study, Etude Sante Psychologique et Traitement, Gothenburg H70 Birth cohort Studies, Hellenic Longitudinal Investigation of Aging and Diet, Korean Longitudinal Study on Cognitive Aging and Dementia, Kurihara Study, Leipzig Longitudinal Study of the Aged, Shanghai Aging Study, Sao Paulo Ageing & Health Study)