Supplementary Table 2. Relative Risk (95% Confidence Interval) of Carotid Atherosclerosis Progression According to Small Dense LDL Related Biomarkers Quartiles.

Variables	No of participants	Plaque progression	Plaque incidence	Multi-territorial extent of new plaque	Total area of new plaque
sdLDLC quartile
< 33 mg/dL	195	Reference	Reference	Reference	Reference
33–47 mg/dL	201	1.29 (0.98–1.70)	1.33 (0.97–1.81)	1.45 (0.95–2.23)	1.43 (0.93–2.21)
48–62 mg/dL	204	1.38 (1.06–1.80)	1.45 (1.07–1.96)	2.08 (1.36–3.20)	1.83 (1.19–2.82)
≥ 63 mg/dL	208	1.68 (1.31–2.17)	1.70 (1.27–2.28)	2.26 (1.46–3.49)	2.42 (1.57–3.75)
sdLDLC/LDLC ratio quartile
< 27%	176	Reference	Reference	Reference	Reference
27–34%	236	1.36 (1.05–1.76)	1.30 (0.98–1.73)	1.44 (0.95–2.18)	1.36 (0.90–2.07)
35–42%	180	1.43 (1.09–1.87)	1.43 (1.07–1.92)	1.73 (1.11–2.68)	1.62 (1.04–2.51)
≥ 43%	216	1.69 (1.29–2.21)	1.77 (1.31–2.38)	2.59 (1.65–4.06)	2.85 (1.81–4.48)

LDL, low-density lipoprotein; No, number; sdLDLC, small dense low-density lipoprotein cholesterol; sdLDLC/LDLC ratio, ratio of small dense LDL cholesterol to LDL cholesterol. Relative risk was calculated using a modified Poisson regression model after adjustment for known cardiovascular disease risk factors, lipid-lowering treatment, and large buoyant LDL cholesterol.