Supplementary Table 3. Relative Risk (95% Confidence Interval) of Carotid Atherosclerosis Progression According to Small Dense LDL Cholesterol / LDL cholesterol Ratio Quartile and Dichotomized LDL Cholesterol.

Variables	No of participants	Plaque progression	Plaque incidence	Multi-territorial extent of new plaque	Total area of new plaque
LDLC < 130 mg/dL + sdLDLC/LDLC ratio < 27%	127	Reference	Reference	Reference	Reference
LDLC < 130 mg/dL + sdLDLC/LDLC ratio 27–34%	105	1.21 (0.87–1.69)	1.17 (0.80–1.70)	0.98 (0.57–1.67)	1.02 (0.59–1.74)
LDLC < 130 mg/dL + sdLDLC/LDLC ratio 35–42%	44	1.12 (0.69–1.81)	1.25 (0.76–2.08)	1.39 (0.71–2.75)	1.42 (0.72–2.82)
LDLC < 130 mg/dL + sdLDLC/LDLC ratio ≥ 43%	81	1.45 (0.95–2.11)	1.60 (0.97–2.47)	2.82 (1.53–5.20)	3.11 (1.67–5.77)
LDLC ≥ 130 mg/dL + sdLDLC/LDLC ratio < 27%	49	0.87 (0.51–1.51)	0.75 (0.41–1.38)	0.68 (0.30–1.54)	0.61 (0.27–1.40)
LDLC ≥ 130 mg/dL + sdLDLC/LDLC ratio 27–34%	131	1.43 (1.02–2.01)	1.22 (0.84–1.77)	1.71 (0.94–3.14)	1.37 (0.74–2.52)
LDLC ≥ 130 mg/dL + sdLDLC/LDLC ratio 35–42%	136	1.48 (1.08–2.02)	1.35 (0.96–1.90)	1.64 (0.95–2.82)	1.43 (0.83–2.46)
LDLC ≥ 130 mg/dL + sdLDLC/LDLC ratio ≥ 43%	135	1.65 (1.22–2.23)	1.66 (1.19–2.30)	2.03 (1.20–3.43)	2.25 (1.33–3.81)

LDL, low-density lipoprotein; LDLC, low-density lipoprotein cholesterol; No, number; sdLDLC/LDLC ratio, ratio of small dense LDLC to total LDLC. Relative risk was calculated using a modified Poisson regression model after adjustment for known cardiovascular disease risk factors, lipid-lowering treatment, and large buoyant LDLC.