Supplementary Table 4. Relative Risk (95% Confidence Interval) of Carotid Atherosclerosis Progression According to Small Dense LDL Cholesterol Quartile and Dichotomized LDL Cholesterol in Participants with Intermediate or Low Cardiovascular Risk.

Variables	No of participants	Plaque progression	Plaque incidence	Multi-territorial extent of new plaque	Total area of new plaque
LDLC < 130 mg/dL + sdLDLC < 33 mg/dL	175	Reference	Reference	Reference	Reference
LDLC < 130 mg/dL + sdLDLC 33–47 mg/dL	88	1.28 (0.93–1.77)	1.27 (0.89–1.82)	1.31 (0.79–2.20)	1.31 (0.79–2.20)
LDLC < 130 mg/dL + sdLDLC 48–62 mg/dL	44	1.25 (0.81–1.93)	1.44 (0.90–2.31)	2.22 (1.17–4.18)	2.12 (1.12–4.00)
LDLC < 130 mg/dL + sdLDLC ≥ 63 mg/dL	20	2.05 (1.36–3.07)	1.96 (1.15–3.34)	3.46 (1.53–5.82)	4.17 (1.83–5.52)
LDLC ≥ 130 mg/dL + sdLDLC < 33 mg/dL	9	0.95 (0.26–3.48)	0.57 (0.07–4.51)	0.99 (0.17–5.93)	1.01 (0.17–5.13)
LDLC ≥ 130 mg/dL + sdLDLC 33–47 mg/dL	95	1.33 (0.89–2.00)	1.34 (0.87–2.09)	1.66 (0.84–3.25)	1.74 (0.89–3.42)
LDLC ≥ 130 mg/dL + sdLDLC 48–62 mg/dL	126	1.45 (1.04–2.02)	1.46 (1.02–2.09)	2.16 (1.22–3.81)	1.87 (1.05–3.30)
LDLC ≥ 130 mg/dL + sdLDLC ≥ 63 mg/dL	109	1.57 (1.15–2.14)	1.40 (0.98–2.00)	1.72 (1.01–2.95)	1.76 (1.03–3.02)

LDL, low-density lipoprotein; LDLC, low-density lipoprotein cholesterol; No, number; sdLDLC, small dense low-density lipoprotein cholesterol. Relative risk was calculated using a modified Poisson regression model after adjustment for known cardiovascular disease risk factors, lipid-lowering treatment, and large buoyant LDLC.