Supplementary Table 1. Multivariable-adjusted hazard ratios for coronary heart disease according to serum small dense low-density lipoprotein cholesterol levels, 2007–2015.

	Serum sdLDL cholesterol level, mg/dL
	Quartile 1	Quartile 2	Quartile 3	Quartile 4	p for trend
	≤ 24.4	24.5–32.8	32.9–43.6	≥ 43.7
Hazard ratio (95% CI)
Model 1	1.00 (Reference)	3.18 (1.25–8.06)	4.12 (1.65–10.33)	5.32 (2.08–13.59)	< 0.001
Model 1 + serum LDL cholesterol	1.00 (Reference)	2.77 (1.07–7.22)	3.28 (1.22–8.80)	3.84 (1.31–11.24)	0.03
Model 1 + serum triglycerides	1.00 (Reference)	3.04 (1.19–7.77)	3.86 (1.51–9.85)	4.71 (1.72–12.93)	0.003
Model 1 + log hs-CRP	1.00 (Reference)	3.23 (1.27–8.21)	4.19 (1.67–10.49)	5.47 (2.14–14.00)	< 0.001
Model 1 + log HOMA-IR	1.00 (Reference)	2.94 (1.15–7.47)	3.88 (1.55–9.73)	4.68 (1.82–12.04)	0.0012

SI conversion factors: To convert mg/dL values to mmol/L, multiply serum sdLDL cholesterol values by 0.02586 and multiply serum triglycerides values by 0.01129.

Abbreviations: CI, confidence interval; hs-CRP, high-sensitivity C reactive protein; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; SD, standard deviation; sdLDL, small dense low-density lipoprotein.

Model 1: Adjusted for age, sex, systolic blood pressure, use of antihypertensive agents, hemoglobin A1c, use of glucose-lowering agents, high density lipoprotein cholesterol, use of statins, body mass index, estimated glomerular filtration rate, electrocardiogram abnormalities, current smoking, current drinking, and regular exercise