Supplementary Table 2. Multivariable-adjusted hazard ratios for coronary heart disease according to serum small dense low-density lipoprotein cholesterol levels excluding subjects with use of lipid-modifying agents (n = 2,651), 2007–2015.

	Serum sdLDL cholesterol level, mg/dL
	Quartile 1	Quartile 2	Quartile 3	Quartile 4	p for trend
	≤ 24.4	24.5–32.8	32.9–43.6	≥ 43.7
No. of events/subjects	5/639	12/675	18/657	29/680
Age-and sex-adjusted incidence rate (per 1,000 person-years)	1.01	2.38	4.38	5.51	< 0.001
Hazard ratio (95% CI)
Age-and sex-adjusted	1.00 (Reference)	2.46 (0.87–7.01)	3.92 (1.45–10.63)	6.56 (2.49–17.28)	< 0.001
Model 1	1.00 (Reference)	2.46 (0.86–7.02)	3.50 (1.27–9.66)	5.25 (1.90–14.48)	< 0.001
Model 1 + serum LDL cholesterol	1.00 (Reference)	1.97 (0.67–5.76)	2.41 (0.81–7.11)	3.06 (0.96–9.73)	0.07
Model 1 + serum triglycerides	1.00 (Reference)	2.45 (0.85–7.06)	3.50 (1.24–9.86)	5.27 (1.77–15.75)	0.002
Model 1 + log hs-CRP	1.00 (Reference)	2.52 (0.88–7.21)	3.59 (1.30–9.91)	5.51 (1.99–15.23)	< 0.001
Model 1 + log HOMA-IR	1.00 (Reference)	2.29 (0.80–6.54)	3.31 (1.20–9.13)	4.74 (1.71–13.15)	0.001

SI conversion factors: To convert mg/dL values to mmol/L, multiply serum sdLDL cholesterol values by 0.02586 and multiply serum triglycerides values by 0.01129.

Abbreviations: CI, confidence interval; hs-CRP, high-sensitivity C reactive protein; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; SD, standard deviation; sdLDL, small dense low-density lipoprotein.

Model 1: Adjusted for age, sex, systolic blood pressure, use of antihypertensive agents, hemoglobin A1c, use of glucose-lowering agents, high density lipoprotein cholesterol, body mass index, estimated glomerular filtration rate, electrocardiogram abnormalities, current smoking, current drinking, and regular exercise