Supplementary Table 3. Multivariable-adjusted hazard ratios for coronary heart disease per 1 SD increment in log-transformed small dense low-density lipoprotein-cholesterol levels in various subgroups of the study population, 2007–2015.

Variables	Persons at risk	No. of events	HR (95% CI) per 1 SD increment in log (serum sdLDL cholesterol levels)	p for heterogeneity
Overall	3,080	79	1.62 (1.23 to 2.16)	-
Sex
Men	1,290	49	1.48 (1.04 to 2.10)	0.77
Women	1,790	30	1.93 (1.21 to 3.10)
Hypertension
No	1,617	22	1.43 (0.86 to 2.39)	0.76
Yes	1,463	57	1.63 (1.17 to 2.28)
Diabetes
No	2,619	50	1.66 (1.17 to 2.34)	0.61
Yes	461	29	1.57 (0.96 to 2.59)
BMI
< 25 kg/m2	2,294	53	1.67 (1.19 to 2.35)	0.92
≥ 25 kg/m2	786	26	1.44 (0.89 to 2/34)
Serum LDL cholesterol
< 120.1 mg/dL	1,538	33	2.01 (1.22 to 3.31)	0.65
≥ 120.1 mg/dL	1,542	46	1.45 (0.92 to 2.28)
Use of lipid-modifying agents
No	2,651	64	1.66 (1.21 to 2.27)	0.38
Yes	428	15	1.50 (0.78 to 2.90)
Current smoking
No	2,465	58	1.67 (1.20 to 2.32)	0.51
Yes	614	21	1.70 (0.97 to 2.96)
eGFR
≥ 60 ml/min/1.73 m2	2,788	140	1.55 (1.15 to 2.09)	0.70
< 60 ml/min/1.73 m2	292	33	2.64 (1.13 to 6.18)

SI conversion factors: To convert mg/dL values to mmol/L, multiply the serum LDL cholesterol value by 0.02586.

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; LDL, low-density lipoprotein; SD, standard deviation; sdLDL, small dense low-density lipoprotein.

The model was adjusted for age, sex, systolic blood pressure, use of antihypertensive agents, hemoglobin A1c, use of glucose-lowering agents, serum high-density lipoprotein-cholesterol, use of lipid-modifying agents, body mass index, estimated glomerular filtration rate, electrocardiogram abnormalities, current smoking, current drinking, and regular exercise.

The variables relevant to the subgroup were excluded from the relevant Cox model.