Supplementary Table 4. The sensitivity and specificity of detecting high-risk subjects who developed coronary heart disease during an 8-year follow-up for each cutoff value of serum small dense low-density lipoprotein cholesterol level.
| Cutoff value of serum sdLDL-C level (mg/dl) | Subjects with a serum sdLDL-C level above the cutoff value among 3,080 subjects |
Number of subjects with a serum sdLDL-C level above the cutoff value among 79 subjects who developed CHD during follo w-up | Sensitivity (%) | Specificity (%) | HR (95% CI) of a serum sdLDL-C level above the cutoff value vs. that below the cutoff valuea) | |
|---|---|---|---|---|---|---|
| Number | Frequency (%) | |||||
| 25 | 2,275 | 73.9 | 71 | 89.9 | 26.6 | 3.10 (1.45–6.63) |
| 30 | 1,806 | 58.6 | 59 | 74.7 | 41.8 | 1.98 (1.15–3.40) |
| 35 | 1,352 | 43.9 | 50 | 63.3 | 56.6 | 2.09 (1.26–3.45) |
| 40 | 1,018 | 33.1 | 36 | 45.6 | 67.3 | 1.52 (0.93–2.46) |
| 45 | 703 | 22.8 | 26 | 32.9 | 77.4 | 1.49 (0.89–2.49) |
| 50 | 513 | 16.7 | 19 | 24.1 | 83.5 | 1.50 (0.86–2.62) |
| 55 | 336 | 10.9 | 16 | 20.3 | 89.3 | 2.08 (1.14–3.78) |
| 60 | 242 | 7.9 | 12 | 15.2 | 92.3 | 2.04 (1.04–3.99) |
Abbreviations: CHD, coronary heart disease; sdLDL-C, small dense low-density lipoprotein-cholesterol.
SI conversion factors: To convert mg/dL values to mmol/L, multiply serum sdLDL cholesterol values by 0.02586.
a)
Adjusted for age, sex, systolic blood pressure, use of antihypertensive agents, hemoglobin A1c, use of glucose-lowering agents, high density lipoprotein cholesterol, use of lipid-modifying agents, body mass index, estimated glomerular filtration rate, electrocardiogram abnormalities, current smoking, current drinking, and regular exercise.