Table 2.
Multivariable binary logistic regression analysis with the fastest 25% eGFR decline as the outcome variable (compared with all other participants or compared with those with stable middle 50% eGFR decline)
| Variable | Fastest 25% eGFR decline vs all other | Fastest 25% eGFR decline vs stable 50% eGFR decline | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| Serum sphingomyelin (1 SD increase in CU)a | 1.36 (1.15, 1.61) | <0.001 | 1.27 (1.06, 1.52) | 0.010 |
| Sex (male = 1) | 1.36 (0.96, 1.92) | 0.083 | 1.25 (0.86, 1.82) | 0.236 |
| Diabetes duration (years) | 1.02 (1.01, 1.04) | 0.006 | 1.03 (1.01, 1.04) | 0.005 |
| Age at diabetes onset (years) | 0.99 (0.97, 1.01) | 0.28 | 1.00 (0.97, 1.02) | 0.644 |
| Smoking (current vs never) | 1.08 (0.74, 1.58) | 0.70 | 1.05 (0.71, 1.57) | 0.80 |
| Smoking (ex vs never) | 1.08 (0.72, 1.63) | 0.71 | 1.06 (0.68, 1.64) | 0.80 |
| Systolic blood pressure (mmHg) | 1.01 (1.00, 1.02) | 0.034 | 1.01 (1.00, 1.02) | 0.061 |
| HbA1c (mmol/mol) | 1.02 (1.01, 1.03) | <0.001 | 1.02 (1.01, 1.03) | <0.001 |
| BMI (kg/m2) | 0.91 (0.86, 0.95) | <0.001 | 0.90 (0.86, 0.95) | <0.001 |
| HDL-cholesterol (mmol/l) | 0.30 (0.19, 0.50) | <0.001 | 0.35 (0.21, 0.61) | <0.001 |
| Triacylglycerols (mmol/l) | 1.27 (1.04, 1.54) | 0.019 | 1.28 (1.03, 1.59) | 0.024 |
25% fastest eGFR decline had a median yearly eGFR decline −4.4 (IQR −6.8, −3.1) ml min−1 1.73 m−2, whereas the stable 50% eGFR decline group had a median yearly eGFR decline −0.9 (IQR −1.4, −0.6) ml min−1 1.73 m−2
aNMR measures are provided in CU based on the trimethylsilyl propanoic acid reference signal