Table 3.
Cox regression models showing the HRs for the progression from macroalbuminuria to ESRD (70 individuals progressed to ESRD out of 161 with macroalbuminuria) depending on serum sphingomyelin level
| Model | Progression to ESRD | |
|---|---|---|
| HRa (95% CI) | p value | |
| Model 1: Serum sphingomyelin | 1.53 (1.24, 1.91) | <0.001 |
| Model 2: Model 1 + sex + age of diabetes onset + diabetes duration + smoking | 1.56 (1.24, 2.00) | <0.001 |
| Model 3: Model 2 + systolic blood pressure | 1.43 (1.14, 1.80) | 0.002 |
| Model 4: Model 3 + HDL-cholesterol | 1.35 (1.06, 1.72) | 0.015 |
| Model 5: Model 4 + triacylglycerols | 1.36 (1.06, 1.73) | 0.015 |
| Model 6: Model 5 + BMI | 1.42 (1.09, 1. 85) | 0.009 |
| Model 7: Model 6 + HbA1c | 1.42 (1.09, 1.86) | 0.010 |
| Model 8: Model 3 + BMI + HbA1c | 1.53 (1.19, 1.97) | 0.001 |
aReported HR increase corresponds to a 1 SD increase in sphingomyelin level