Table 4.
Cox regression model showing the HRs for incident CHD depending on serum sphingomyelin level (110 individuals suffered an incident CHD event out of 1087 individuals included in the study)
| Model | Incident CHD | |
|---|---|---|
| HRa (95% CI) | p value | |
| Model 1: Serum sphingomyelin | 1.44 (1.19, 1.73) | <0.001 |
| Model 2: Model 1 + sex + age of diabetes onset + diabetes duration + smoking | 1.24 (1.01, 1.52) | 0.038 |
| Model 3: Model 2 + systolic blood pressure | 1.21 (0.98, 1.49) | 0.07 |
| Model 4: Model 3 + HDL-cholesterol | 1.21 (0.99, 1.48) | 0.06 |
| Model 5: Model 4 + triacylglycerols | 1.17 (0.96, 1.43) | 0.13 |
| Model 6: Model 5 + BMI | 1.18 (0.96, 1.44) | 0.11 |
| Model 7: Model 6 + HbA1c | 1.13 (0.92, 1.39) | 0.24 |
| Model 8: Model 3 + BMI + HbA1c | 1.16 (0.94, 1.43) | 0.18 |
The incidence of CHD was 8.2 per 1000 person-years
aReported HR increase corresponds to a 1 SD increase in sphingomyelin level