Table 1.
Descriptive characteristics of the study cohorts of ART treatments in women with a history of type 1 diabetes, type 2 diabetes or uncategorised diabetes and without a history of diabetes during the study period (1 January 2006 to 31 December 2017)
| Characteristic | Exposed cohort | Unexposed cohort | ||
|---|---|---|---|---|
| Embryo transfers in women with type 1 diabetes (N = 538)a |
Embryo transfers in women with type 2 diabetes (N = 518)b |
Embryo transfers in women with uncategorised diabetes (N = 682)c |
Embryo transfers in women without diabetes (N = 127,599)d |
|
| Median (25th–75th percentile) age at embryo transfer, years | 34 (30–38) | 36 (32–38) | 35 (32–38) | 34 (30–38) |
| Median (25th–75th percentile) partner’s age at embryo transfer, years | 36 (32–39) | 37 (33–40) | 36 (33–41) | 36 (32–40) |
| Female/male factor infertility, n (%) | ||||
| Female factor | 97 (18.0) | 93 (18.0) | 130 (19.1) | 19,275 (15.1) |
| Male factor | 168 (31.2) | 112 (21.6) | 191 (28.0) | 40,990 (32.1) |
| A mixture of factors/idiopathic | 273 (50.7) | 313 (60.4) | 361 (52.9) | 67,270 (52.7) |
| Type of preceding treatment, n (%) | ||||
| IVF | 192 (36.6) | 229 (45.4) | 271 (40.1) | 47,061 (37.2) |
| ICSI | 206 (39.2) | 150 (29.8) | 247 (36.6) | 47,935 (37.9) |
| FER | 127 (24.2) | 125 (24.8) | 157 (23.3) | 31,490 (24.9) |
| BMI, n (%) | ||||
| <18.5 kg/m2 (underweight) | 15 (3.4) | 0 (0.0) | 3 (0.5) | 3518 (3.4) |
| 18.5–25 kg/m2 (normal weight) | 234 (53.3) | 71 (17.7) | 188 (33.8) | 67,002 (64.1) |
| 25–30 kg/m2 (pre-obesity) | 130 (29.6) | 138 (34.4) | 162 (29.1) | 23,990 (23.0) |
| 30–35 kg/m2 (obese I) | 54 (12.3) | 142 (35.4) | 155 (27.9) | 8189 (7.8) |
| ≥35 kg/m2 (obese II–III) | 6 (1.4) | 50 (12.5) | 48 (8.6) | 1796 (1.7) |
| Smoking at the time of embryo transfer, n (%) | 38 (8.6) | 48 (12.1) | 60 (10.8) | 8684 (8.4) |
| Alcohol consumer, n (%) | 191 (45.4) | 78 (21.3) | 158 (30.0) | 44,636 (44.8) |
| Calendar year of infertility treatment, n (%) | ||||
| 2006–2009 | 189 (35.1) | 199 (38.4) | 258 (37.8) | 38,259 (30.0) |
| 2010–2013 | 161 (29.9) | 165 (31.9) | 253 (37.1) | 42,305 (33.2) |
| 2014–2017 | 188 (34.9) | 154 (29.7) | 171 (25.1) | 47,035 (36.9) |
| Parity, n (%) | ||||
| 0 | 197 (36.6) | 162 (31.3) | 269 (39.4) | 49,612 (38.9) |
| 1+ | 341 (63.4) | 356 (68.7) | 413 (60.6) | 77,987 (61.1) |
| Comorbidity at embryo transfer, n (%) | ||||
| No comorbidity | 431 (80.1) | 419 (80.9) | 559 (82.0) | 113,726 (89.1) |
| Some comorbidity | 107 (19.9) | 99 (19.1) | 123 (18.0) | 13,873 (10.9) |
aNo. of women in the exposed type 1 diabetes cohort: 187. Percentage with missing data: age of partner 8.8%, ART treatment 2.4%, BMI 18.4%, smoking at the time of embryo transfer 18.0%, alcohol 21.7%
bNo. of women in the exposed type 2 diabetes cohort: 170. Percentage with missing data: age of partner 7.5%, ART treatment 2.7%, BMI 22.6%, smoking at the time of embryo transfer 23.4%, alcohol 29.2%
cNo. of women in the exposed uncategorised diabetes cohort: 237. Percentage with missing data: age of partner 5.4%, ART treatment 1.0%, BMI 18.5%, smoking at the time of embryo transfer 18.2%, alcohol 22.9%
dNo. of women without a history of diabetes cohort: 42,688. Percentage with missing data: age of partner 6.8%, fertility factor 0.1%, ART treatment 2.4%, BMI 18.1%, smoking at the time of embryo transfer 18.9%, alcohol 22.0%