Fig. 2.

Congenital hypothyroidism alters glucose metabolism in female offspring. Adult female offspring (8–10 weeks of age) were analysed. (a) Female offspring weight over time after birth (n = 15 mice/group, one-way ANOVA). (b) Total plasma T₄ concentration in adult female offspring (n = 5–10 mice/group, Mann–Whitney U test). (c) Fasting blood glucose in adult female offspring (n = 15 mice/group, Mann–Whitney). (d) IPGTT (3 g/kg) (n = 10 mice/group, two-way ANOVA) and AUC analysis (n = 10 mice/group, Mann–Whitney). (e) Fasting insulin concentrations (n = 10 mice/group, Mann–Whitney). (f) ITT (0.75 U/kg) and AUC analysis (n = 10 mice/group, Mann–Whitney). (g) In vivo insulin responses to glucose (3 g/kg) (n = 10 mice/group, one-way ANOVA). *p < 0.05, **p < 0.01 using the tests indicated above. Data are mean ± SEM. gest, gestation