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. 2020 Jul 30;14:31. doi: 10.3389/fnana.2020.00031

FIGURE 9.

FIGURE 9

Regional differences in vascularization correlate with regional differences in astrocyte density. (A,B) The area occupied by CD31-IR and VIM-IR blood vessels was significantly greater in cortical than in subcortical regions. (C) There were no significant differences in the area occupied by CD31-IR blood vessels between mouse brain regions, but this coverage was substantially lower that that measured in human samples (A,B). (D) Human VIM-IR and GFAP-IR astrocyte density negatively correlated with CD31-IR vascularization across regions. One value from the caudate nucleus was excluded as an outlier for both regressions, and both the thalamus and cortical white matter values were excluded from the VIM-IR density regression as VIM-IR cells were mostly absent from these regions. Scale bars = 50 μm. n.s. p > 0.05, ****p ≤ 0.0001 (Human: n = 8; Mouse: n = 5; Matched One-Way ANOVAs).