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Representative chromatograms of apocynin detected using HPLC‐MS/MS. Control sample (top panel) was apocynin (500 ng/mL) spiked into mouse plasma and was detected as a prominent peak at ~5.5‐5.7 min. Apocynin was detected in the plasma, brain, liver, and heart samples harvested at 5 min and in urine samples harvested at 15 min after intravenous injection. HPLC‐MS/MS, HPLC coupled to a quadrupole‐linear ion‐trap tandem mass spectrometry
