TABLE 1.
Pharmacokinetic parameters of apocynin simulated using WinNonlin 8.1 software (n = 3)
| Pharmacokinetic parameters | Units | NCA | Time point: 0‐6 h | |||
|---|---|---|---|---|---|---|
| 1‐CA | 2‐CA | 3‐CA | ||||
| C 0 | ng/mL | 7359.89 | — | — | — | |
| C max | ng/mL | 5494.00 | — | — | — | |
| AUC0‐30min | ng/mL/h | 643.47 | — | — | — | |
| AUC0‐∞ | ng/mL/h | 644.27 | 681.33 | 711.10 | 711.07 | |
| t 1/2 | h | 0.05 | — | — | — | |
| Kel | 1/h | 13.65 | — | — | — | |
| CL | mL/h/kg | 7760.69 | — | — | — | |
| tvCL1 | mL/h | — | 5541.14 | 5540.91 | 5521.18 | |
| tvCL2 | mL/h | — | — | 0.17 | 4.03 | |
| tvCL3 | mL/h | — | — | — | 16.45 | |
| V d | mL/kg | 568.74 | — | — | — | |
| tvV1 | mL | — | 530.72 | 530.72 | 530.71 | |
| tvV2 | mL | — | — | 0.37 | 63.99 | |
| tvV3 | mL | — | — | — | 51.90 | |
| LogLik | — | — | −186.25 | −186.25 | −186.25 | |
| −2LL | — | — | 372.50 | 372.50 | 372.50 | |
| AIC | — | — | 378.50 | 382.50 | 386.50 | |
| AICc | — | — | 379.70 | 385.84 | 393.50 | |
| BIC | — | — | 382.04 | 388.39 | 394.75 | |
| nParm | — | — | 3 | 5 | 7 | |
| nObs | — | — | 24 | 24 | 24 | |
Abbreviations: 1‐CA, 2‐CA or 3‐CA, one, two or three compartmental analysis (values were from 0 to 6 h); AIC, Akaike information criterion; AICc, AIC corrected; AUC0‐30 min, Area under the curve from time 0 to 30 min; AUC0‐∞, Area under the curve from time 0 extrapolated to infinite time; BIC, Bayesian information criterion; C 0, extrapolated plasma concentration at time 0; CL, clearance; C max, maximum plasma concentration; Kel, elimination rate constant; LogLik, log likelihood; NCA, non‐compartmental analysis (values were from 0 to 30 min, R 2 = .93); nObs, number of observations; nPharm, number of PK parameters; t 1/2, terminal half‐life; tvCL1, tvCL2 or tvCL3, typical value (tv) of one, two and three compartmental clearance; tvV1, tvV2 or tvV3, typical value (tv) of one, two or three compartmental volume of distribution; V d, volume of distribution.