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. 2020 Jul 30;11:1089. doi: 10.3389/fphar.2020.01089

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Copyright © 2020 Yang, Cao, Zhou, Zhu, Wang, Zhang, Kwok, Zhang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapy of NSCLC xenografts with B7-H3 CAR-NK-92MI cells. (A) Treatment procedures of NOD/SCID mice inoculated subcutaneously with A549 cells. (B) Tumor growth in NOD/SCID mice with treatments of CAR-NK-92MI cells compared to NK-92MI cells (**p < 0.01) and PBS (***p = 0.001). (C) Survival of mice by Kaplan-Meier survival analysis for CAR-NK-92MI cells compared to NK-92MI cells (*p < 0.05) and PBS (**p < 0.01). n = 5 each group.