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Antibody allostery. The theory of antibody allostery or “intramolecular signaling” asserts that (1) an apo-IgG has flexibility that impedes its affinity to FcγRs. (2) Antigen binding generates an allosteric signal from the Fab to Fc domain. (3) Allostery causes a conformational change in the Fc as well as decreased flexibility that facilitates FcγR binding with higher affinity.
