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Potential model for IgG effector function fate. (1) Free IgG binds to antigen, (2) causing a change in presentation of the IgG Fc domain. (3) Depending on the arrangement of antigen and/or antibody phenotype, Fc-Fc interactions are facilitated in different oligomeric arrangements. (4) Specific arrangements of Fc-Fc domains influence the binding of FcγRs or C1q, thus resulting in ADCC, CDC or potentially other effector functions.
