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. 2020 Jul 30;11:1635. doi: 10.3389/fimmu.2020.01635

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Copyright © 2020 Murin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of lipid composition on ADCC. (A) Lipid rafts containing activating receptors and higher levels of cholesterol tend to be more rigid and isolated in the plasma membrane of resting or inactive NK cells. Actin cytoskeletal rearrangements are thought to aid in bringing lipid rafts together in order to allow tighter clustering of signaling molecules and increased cytolytic activity. (B) Target cell membrane lipid composition may aid or inhibit NK cell ADCC by how well antibody coated antigen is able to cluster, thus promoting FcγRIIIa receptor clustering.