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. 2020 Jul 30;11:1635. doi: 10.3389/fimmu.2020.01635

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Copyright © 2020 Murin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular basis of effector cell activation. (A) Dimers are prevalent molecular motifs in cellular activation throughout the immune system. (B) Potential dimer model of IgG-FcγR-CD3 ζζ activation complex, based off structures of complex components [FcγRIIb-Fc from PDB-3RY6 overlaid on FcγRIIb crystal contact dimers from PDB-3RY5; model of transmembrane assembly of CD3 ζζ structure from PDB-2HAC and model of FcγRIIIa/adapter assembly from Blazquez-Moreno et al. (184)]. (C) Potential model of downstream antibody-mediated signaling based on the “rotation model,” which postulates that intracellular kinase domains are exposed for phosphorylation upon proper dimer assembly when extracellular activating ligands bind.