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. 2020 Jul 30;8:735. doi: 10.3389/fcell.2020.00735

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Copyright © 2020 Heng, Zhang, Aubel, Bai, Li, Wei, Fussenegger and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical YAP/TAZ expression profile in tissues/organs during normal development and homeostasis. (A) Early embryonic and fetal development are typically associated with high levels of YAP/TAZ activity, which are gradually downregulated after birth, as growth during the juvenile phase slows down, (B) finally reaching basal levels at the quiescent state of mature adult tissues/organs. (C) At the onset of tissue/organ injury, the mobilization and rapid proliferation of endogenous adult stem/progenitor cells are associated with highly elevated YAP/TAZ expression levels, which (D) return to basal levels of the quiescent state after organ/tissue healing and regeneration is completed.