TABLE 2.

Performance for the full model, factor groups and individual factors for detecting amyloid positivity.

	Amyloid + relative to amyloid-	AUC (95% CI)
Composite DSI		0.78 (0.65–0.91)
Demographic		0.54 (0.37–0.70)
Sex/Female	↓	0.48 (0.35–0.60)
Age	↑	0.45 (0.28–0.61)
Education (years)	↓	0.59 (0.43–0.75)
Cardiovascular		0.60 (0.46–0.75)
Body mass index	↓	0.65 (0.50–0.79)
High blood pressure	↑	0.49 (0.37–0.61)
APOE (e4 carrier)	↑	0.69 (0.56–0.82)
Cognition		0.65 (0.49–0.81)
mNTB Total	↓	0.55 (0.38–0.72)
mNTB Memory	↑	0.54 (0.38–0.70)
mNTB Processing speed	↓	0.57 (0.41–0.73)
mNTB Executive function	↓	0.69 (0.53–0.84)
MRI		0.75 (0.61–0.89)
Volumes		0.72 (0.57–0.88)
Total cortex	↓	0.73 (0.59–0.88)
Total gray matter	↓	0.72 (0.57–0.88)
Cerebellum cortex	↓	0.69 (0.54–0.84)
Thalamus proper	↓	0.70 (0.55–0.85)
Caudate	↓	0.65 (0.49–0.81)
Putamen	↓	0.71 (0.56–0.87)
Pallidum	↓	0.61 (0.45–0.77)
Brain Stem	↓	0.61 (0.45–0.77)
Hippocampus	↓	0.70 (0.54–0.86)
Amygdala	↓	0.69 (0.53–0.85)
Accumbens area	↓	0.75 (0.62–0.89)
Ventral diencephalon	↓	0.68 (0.53–0.83)
Cerebrospinal fluid	↓	0.61 (0.44–0.78)
Optic chiasm	↓	0.60 (0.41–0.78)
Total corpus callosum	↓	0.62 (0.45–0.79)
Visual MTA rating (Scheltens)	↑	0.71 (0.59–0.84)
AD-signature cortical thickness	↓	0.65 (0.48–0.82)

Upward arrow indicates the amyloid + group having a larger mean value. AUC values (95% confidence interval) are from 100 × 5-cross-validation. AUC, area under the receiver operating characteristic curve; DSI, disease state index; APOE, Apolipoprotein E; mNTB, modified neuropsychological test battery; MRI, magnetic resonance imaging; MTA, medial temporal lobe atrophy; AD, Alzheimer’s disease.