Table 2.
Univariate and multivariate cox analysis for risk factors of relapse.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Clinical stage, Metastatic vs. Localized | 0.92 (0.21–4.05) | 0.917 | - | - |
| Tumor size, ≥4 vs. <4 cm | 0.96 (0.31–2.99) | 0.947 | - | - |
| Differentiation, Poor vs. Other | 3.08 (0.99–9.56) | 0.074 | 2.30 (0.51–10.45) | 0.279 |
| Lymph node metastasis, Positive vs. Negative | 1.55 (0.41–5.77) | 0.469 | 1.14 (0.29–4.50) | 0.850 |
| Nerve invasion, Positive vs. Negative | 1.96 (0.62–6.24) | 0.302 | 1.51 (0.35–6.43) | 0.578 |
| Vascular invasion, Positive vs. Negative | 3.16 (0.93–10.79) | 0.036* | 1.50 (0.23–9.82) | 0.673 |
| Postoperative CA19-9 level, Elevated vs. Normal | 2.69 (0.57–12.75) | 0.084 | - | - |
| Preoperative ctDNA status, Positive vs. Negative | 0.65 (0.20–2.05) | 0.453 | ||
| Postoperative ctDNA status, Positive vs. Negative | 3.55 (0.90–13.89) | 0.019* | 3.60 (1.15–11.28) | 0.028*a |
*
Statistical significance.
a
Multivariate analysis was performed to adjust for the potential effects of differentiation, lymph node metastasis, nerve invasion, and vascular invasion.