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Development of irAEs and unexpected critical complications among the three subgroups of frailty (age <75 years).
| Variables | Low frailty (FS=0) (n=75), n (%) | Intermediate frailty (FS=1) (n=51), n (%) | High frailty (FS=2, 3) (n=13), n (%) | P-value |
|---|---|---|---|---|
| Total of irAEs | 35 (46.7) | 15 (29.4) | 2 (15.4) | 0.09 |
| Grade 3–5 irAEs | 5 (6.7) | 5 (9.8) | 2 (15.4) | 0.55 |
| Unexpected critical complications | Worsening of preexisting dermatomyositis (n=1) | None | None |
irAEs, immune related adverse events; FS, frailty score.
