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. 2020 Jul 30;11:1170. doi: 10.3389/fphar.2020.01170

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Copyright © 2020 Ye, Lu, Wang, Ge, Liu, Qi, Fu, Zhang, Zhang, Sun and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hydroxysafflor yellow A (HSYA) reduces myocardial apoptosis. (A, B) Representative images and analysis results of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. Scale bar, 200 μm. (C–F) Representative immunoblots and quantified analysis of cleaved caspase-3, Bax, and Bcl-2 expression. Data are presented as means ± SEM (n = 3). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. the sham group, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the ischemia/reperfusion (I/R) group.