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. 2020 Jul 30;11:1170. doi: 10.3389/fphar.2020.01170

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Copyright © 2020 Ye, Lu, Wang, Ge, Liu, Qi, Fu, Zhang, Zhang, Sun and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hydroxysafflor yellow A (HSYA) inhibits the expression of NLRP3 inflammasome. (A–C) Immunohistochemical staining measuring NLRP3, ASC, and caspase-1 expressions in heart tissues of rats. (D–F) Quantification of NLRP3, ASC, and caspase-1 staining. (G) Western blot showing the protein expression levels of NLRP3, caspase-1, and cleaved interleukin (IL)-1β. (H–J) The ratios of NLRP3, caspase-1, and cleaved IL-1β and β-tubulin were quantified by densitometry based on immunoblot images. Data are presented as means ± SEM. ^#P < 0.05, ^###P < 0.01 vs. the sham group, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the ischemia/reperfusion (I/R) group.