Table 4.
Metabolic profile score Tpred association with phenotypic traits adjusted for age, gender, smoking, alcohol consumption and study centre at baseline, the IMI DIRECT cohorts.
|
Cohort I n = 403 |
Cohort II n = 458 |
|||||
|---|---|---|---|---|---|---|
| β a | 95% CI | P value | β a | 95% CI | P value | |
| Waist circumference (cm) | −0.9 | −2.1, 0.3 | 0.09 | −1.5 | −2.9, 0.08 | 0.06 |
| Weight (kg) | −1.8 | −3.2, −0.4 | 0.01 | −2.1 | −3.8, −0.2 | 0.03 |
| Body mass index (kg/m2) | −0.5 | −1.0, −0.1 | 0.02 | −0.5 | −1.1, 0.1 | 0.09 |
| Liver fat (%) | −0.97 | −0.82, 1.11 | 0.63 | −0.74 | −0.67, −0.81 | <0.0001 |
| Fasting HbA1c (mmol/mol)† | −0.4 | −0.7, −0.01 | 0.04 | −0.9 | −1.5, −0.1 | 0.02 |
| Fasting glucose (mmol/L)† | 0.04 | −0.04, 0.1 | 0.32 | −0.2 | −0.4, −0.05 | 0.01 |
| Fasting insulin (pmol/mol)† | 0.2 | −0.7, 0.7 | 0.88 | −11.0 | −19.5, −2.6 | 0.01 |
| Fasting triglycerides (mmol/L) | −0.1 | −0.2, −0.03 | 0.003 | −0.2 | −0.3, −0.09 | 0.0002 |
| Fasting LDL-cholesterol (mmol/L) | 0.001 | −0.1, 0.1 | 0.86 | −0.06 | −0.2, 0.04 | 0.24 |
| Fasting HDL-cholesterol (mmol/L) | 0.07 | 0.03, 0.1 | <0.0001 | 0.08 | 0.04, 0.1 | 0.0002 |
Abbreviations: Cohort I; participants with normal or impaired glucose regulation, Cohort II; participants with type 2 diabetes, HDL; high density lipoprotein cholesterol, LDL; low density lipoprotein cholesterol, HbA1c; glycated haemoglobin. a: Generalised linear regression model coefficient represents the mean change in the phenotypic trait for one unit change (increase) in Tpred score.
†
Cohort II is additionally adjusted for usage of glucose lowering medication.