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NBMI treatment induces down-regulation of age-1. Synchronized L1 stage worms were treated with 0-1000 μM NBMI for 24 h, followed by mRNA extraction and q-PCR. Worms in the 0 μM NBMI group received 0.1 % DMSO as vehicle control. (a-c) relative mRNA levels of genes: daf-16 (a), daf-2 (b) and age-1 (c). * p < 0.05, ** p < 0.01 compared with the control group (one-way ANOVA followed by Tukey’s post hoc test; n = 3).
